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Prognostic Value of the Hyperdense Middle Cerebral Artery Sign and Stroke Scale Score Before Ultraearly Thrombolytic Therapy AJNR 17:79-85, Tomsick,T.,et al, 1996 See this aricle in Pubmed Article Abstract The presence of the HMCAS on CT scans obtained within 90 minutes of stroke onset is associated with a major neurological deficit,and in this study it predicted a poor clinical and radiologic outcome after intravenous thrombolytic therapy.However,a major neurologic deficit,defined as a stroke scale score of 10 or more,was better than a positive HMCAS as a predictor of poor neurologic outcome after thrombolytic therapy.Patients with a low stroke scale score(<10)may benefit from ultraearly intravenous alteplase therapy.

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