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The Optic Neuritis Treatment Trial(ONTT)is a prospective study of corticosteroid treatment of acute optic neuritis(ON)with subsequent longitudinal followup to determine development of clinically definite multiple sclerosis(CDMS).No patients had their diagnosis or management altered as a result of CSF findings.Except for oligoclonal bands,few patients showed any abnormalities on CSF tests,and no tests correlated with the two year development of CDMS.Oligoclonal banding,present at baseline in 11 of 13 patients who developed CDMS,did predict progression to CDMS,but this was not independent of MRI abnormalities.Two patients with oligoclonal bands and a normal MRI did progress to CDMS.We conclude that CSF analysis may not be necessary in the routine evaluation of patients presenting with a typical clinical profile of acute ON,and that most CSF tests add little additional information to MRI results for predicting the two year development of CDMS.However,the precise role of oligoclonal banding in the analysis of such patients awaits longer followup of this cohort. |
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cerebrospinal fluid
cerebrospinal fluid,abnormal
cerebrospinal fluid,oligoclonal IgG in
MRI
MRI,abnormal
multiple sclerosis
optic neuritis
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