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Valproic Acid Hepatic Fatalities. III. U. S. Experience Since 1986
Neurol 46:465-469, Bryant,A.E.&Dreifuss,F., 1996
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Article Abstract
We report the results of a third retrospective study of the U.S.experience with fatal hepatotoxicity associated with valproic acid(VPA).In the United States,over one million patients received new prescriptions for VPA during the years 1987 to 1993 and 29 patients developed fatal hepatotoxicity. Decreased alertness,jaundice,vomiting,hemorrhage,increased seizures, anorexia and edema were the most common presenting signs.Risk factors included young age,polytherapy,developmental delay,and coincident metabolic disorders.Patients less than 2 years old receiving VPA as polytherapy were at the greatest risk(1:600)of developing this complication.
 
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adverse drug reaction
anticonvulsants
anticonvulsants,untoward effects of
developmental retardation
hepatic failure
liver disease
liver transplantation
mortality
polypharmacy
review article
risk factors
sodium valproate
sodium valproate,toxicity
treatment of neurologic disorder

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