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An Increased Frequency of Patent Foramen Ovale in Patients with Transient Global Amnesia
Arch Neurol 53:504-508, Klotzsch,C.,et al, 1996
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Article Abstract
Using contrast transcranial Doppler sonography we have observed a PFO in 55%of the patients with TGA,compared with 27%of a control group of 100 patients.This difference was statistically significant(P<.01).Twenty-five patients with TGA(47%),15 of them with a proven PFO,reported a precipitating activity,such as the lifting of heavy weights,immediately before the TGA occurred.In addition to other pathological mechanisms, paradoxical embolism with temporobasal ischemia could possibly play a role in the clinical syndrome of TGA.This hypothesis could explain the frequent observation of preceding Valsalvalike activities in patients with TGA.
 
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cerebral embolism
cerebral ischemia
cerebrovascular accident
embolism,paradoxical
patent foramen ovale
precipitating factors
transient global amnesia
transient global amnesia,precipitating events
valsalva maneuver

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