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Clinical and Subclinical Neurological Involvement in Children of Conjugal Multiple Sclerosis Patients Multiple Sclerosis 1:170-172, Constantinescu,C.S.,et al, 1996 See this aricle in Pubmed Article Abstract We report the occurrence of clinically definite multiple sclerosis in an offspring of a couple with conjugal multiple sclerosis.Extensive investigation of all members of this family,which includes two additional asymptomatic children,eliminated the possibility of alternative neurological diagnoses.All family members were studied with magnetic resonance imaging(MRI),evoked potentials,and human leukocyte antigen(HLA) typing.An asymptomatic child had subtle white matter abnormalities on MRI, suggesting subclinical neurological involvement.This study documents the third case of multiple sclerosis in the child of conjugal multiple sclerosis patients and provides the first report of MRI lesions in an asymptomatic offspring of the same parents.Neurodiagnostic and immunogenetic investigations of such rare family clusters may contribute to the elucidation of the pathogenesis of multiple sclerosis.

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(click to filter results - removes previous filter) evoked potentials familial HLA MRI MRI,abnormal multiple sclerosis multiple sclerosis,conjugal multiple sclerosis,familial

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