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Central nervous system(CNS)abnormalities were identified on MRI in 17.9%of the children(22.2%of children homozygous for HbS),and a clinical history of CVA(N=9,4.6%)was identified in only children with HbSS disease. Subsequent analyses examined only children with HbSS.Children with a history of CVA performed significantly poorer than children with silent infarcts or no MRI abnormality on most neuropsychological evaluation measures.Children with silent infarcts on MRI performed significantly poorer than children with no MRI abnormality on tests of arithmetic, vocabulary,and visual motor speed and coordination.These results substantiate the importance of careful evaluation,educational planning,and medical intervention for CNS-related complications in children with sickle cell disease. |
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asymptomatic
cerebrovascular accident
cerebrovascular accident,silent
cognition
MRI
MRI,abnormal
psychological testing
psychological testing,children
psychological testing,neurologic problems
sickle cell disease
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