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Several case reports have suggested an association between human T-cell lymphotropic virus type II(HTLV-II)infection and chronic neurologic disease.We performed serial neurological examinations in injection-drug users(IDU),a group known to be at increased risk for HTLV-II infection.At baseline,those infected with HTLV-II alone,human immunodeficiency virus (HIV)alone,or both were significantly more likely to have neurologic disability than uninfected subjects.Longitudinally,HTLV-II infection was independently associated with the development of global neurologic disability and neuropathy,suggesting that HTLV-II causes neurologic disease. |
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