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Congenital Muscular Dystrophy Syndromes Distinguished by Alkaline and Acid Phosphatase, Merosin, & Dystrophin Staining
Neurol 46:810-814, Connolly,A.M.,et al, 1996
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Article Abstract
Congenital muscular dystrophy syndromes are characterized by congenital weakness,contractures,and dystrophic features on muscle biopsy.However, these syndromes are often difficult to diagnose precisely because their clinical and pathologic characteristics are not specific and resemble changes in other myopathies.We conclude that a pattern of few AcP-positive cells in the setting of numerous AlkP staining muscle fibers has specificity for congenital muscular dystrophy syndromes and provides histopathologic support for the diagnosis.Reduced merosin in muscle predicts more severe weakness and long-term disability.
 
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contractures,joint
creatine phosphokinase(CPK)elevated
developmental retardation
disability,neurological
dystrophin
histochemistry
histochemistry of muscle
mental retardation
merosin
muscle biopsy
muscle weakness
muscular dystrophy
muscular dystrophy,central nervous system abnormality
muscular dystrophy,congenital
prognosis
weakness,congenital
weakness,generalized

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