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Independent negative predictors of survival include elevated CSF protein and clinical involvement of the cerebral leptomeninges.Independent positive predictors of survival were longer duration of neurological symptoms at the time of presentation,treatment with intrathecal or intraventricular(intra-CSF)chemotherapy and female sex.Other variables including age,primary tumor type and extent of systemic disease,were not predictive.We conclude that female sex,longer duration of neurological symptoms,absence of cerebral leptomeningeal clinical involvement and absence of elevated CSF protein independently predict better survival. Patients treated with intra-CSF chemotherapy also survived longer. |
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cerebrospinal fluid cerebrospinal fluid,abnormal cerebrospinal fluid,biochemical markers of CNS tumors cerebrospinal fluid,elevated protein of chemotherapy,CNS treatment and complications with intrathecal chemotherapy intrathecal treatment of meningitis meningitis,carcinomatous mental status,abnormal MRI MRI,abnormal MRI,spine neoplasm,metastatic to CNS neurologic signs neurologic symptoms prognosis review article
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