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The Natural Course of Cerebral Lesions in Sneddon Syndrome
Arch Neurol 54:53-60, Tourbah,A.,et al, 1997
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Article Abstract
The age at the first cerebral ischemic event ranged from 22 to 58 years. Motor deficit was the most frequent sign(found in 73%of cases).Disability was found in 50%,systemic hypertension in 65%,heart valvulopathy in 61%, and antiphospholipid antibodies in 42%of cases.Patients were classified in 6 groups according to magnetic resonance imaging findings.No correlation was found between the presence of hypertension or other vascular risk factors,valvulopathy,antiphospholipids,and magnetic resonance imaging abnormalities.There was no significant difference between antiphospholipid-positive and antiphospholipid-negative patients except for the presence of antinuclear antibodies.There was a significant correlation between the extent of magnetic resonance imaging abnormalities and disability.The severity of the disease seems to be correlated with magnetic resonance imaging aspects,but not to the presence of antiphospholipid antibodies.Magnetic resonance imaging may help to understand the natural course of the cerebral involvement of the disease.
 
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antiphospholipid antibodies
aortic valve,lesion of
cerebrovascular accident
cerebrovascular accident,young adult
echocardiogram
hypertension
livedo reticularis
migraine
mitral valve lesion
MRI
MRI,abnormal
prognosis
Sneddon's syndrome

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