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Painful Vasculitic Neuropathy in HIV-1 Infection:Relief of Pain with Prednisone Therapy Neurol 47:1446-1451, Bradley,W.G.&Verma,A., 1996 See this aricle in Pubmed Article Abstract Painful distal sensory polyneuropathy(DSP)is the most common peripheral neuropathy in patients with human immunodeficiency virus-1(HIV-1) infection.There is no specific therapy for DSP,and nonspecific treatment with pain blockers and narcotic agents generally fails to adequately control the symptoms.We report two patients who had subacute painful neuropathy in the B2(formerly AIDS-related complex[ARC]stage of HIV-1 infection.Neurophysiologic studies revealed predominantly axonal sensorimotor neuropathy.Sural nerve biopsy in both cases showed a necrotizing vasculitis.Treatment with corticosteroids resulted in rapid relief of pain,followed by arrest of the neuropathic process.Although not previously emphasized,vasculitic neuropathy must be considered among the treatable causes of painful sensory neuropathy in HIV-1-infected individuals.

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(click to filter results - removes previous filter) human immunodeficiency virus type 1 nerve biopsy neuropathy neuropathy,painful neuropathy,vasculitic,nonsystemic pain steroid steroid therapy,CNS treatment and complications with treatment of neurologic disorder vasculitides

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