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Massive Nerve Root Enlargement in Chronic Inflammatory Demyelinating Polyneuropathy
JNNP 61:636-640, Schady,W.,et al, 1996
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Article Abstract
Clinically,peripheral nerve thickening was slight or absent.Subsequently one patient developed facial nerve hypertrophy.This was mistaken for an inner ear tumor and biopsied with consequent facial palsy. Neurophysiological tests suggested a demyelinating polyneuropathy.Sural nerve biopsy showed in all cases some loss of myelinated fibers, inflammatory cell infiltration and a few onion bulbs.Hypertrophic changes were much more prominent on posterior nerve root biopsy in one patient; many fibers were surrounded by several layers of Schwann cell cytoplasm. There was an excellent response to steroids in two patients but not in the third(most advanced)patient,who has benefited only marginally from intravenous immunoglobulin therapy.MRI of the cauda equina may be a useful adjunct in the diagnosis of CIDP.
 
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CAT scan,abnormal
CAT scan,myelogram with
cauda equina
cauda equina,lesion of
cranial nerve enlargement
cranial nerve palsies
cranial nerves
facial nerve
MRI
MRI,abnormal
MRI,cranial nerves
nerve hypertrophy
nerve root hypertrophy
polyneuropathy,chronic inflammatory demyelinating
steroid therapy,CNS treatment and complications with
treatment of neurologic disorder

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