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Among these patients,103(4.6%)had fatal or nonfatal strokes during the study(rate of stroke per year of followup,1.5%).The estimated five year rate of stroke in all the patients was 8.1%.As compared with patients without stroke,patients with stroke were older(mean age 63.9 years vs 59. 11 years)and had lower ejection fractions(29.7%vs 3l.7%).Independent risk factors for stroke included a lower ejection fraction(for every decrease of 5%points in the ejection fraction there was an 18%increase in the risk of stroke),older age,and the absence of aspirin or anticoagulant therapy. Patients with ejection fractions of<28%after MI had a relative risk of stroke of 1.86 as compared with patients with ejection fractions of>35%. The use of thrombolytic agents and captopril had no significant effect on the risk of stroke.During the five years after myocardial infarction, patients have a substantial risk of stroke.Anticoagulant therapy appears to have a protective effect against stroke after myocardial infarction. |
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anticoagulant,treatment
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cerebral infarction
cerebrovascular accident
cerebrovascular accident,prevention of
coumarin
ejection fraction
ejection fraction,abnormal
myocardial infarction
old age,neurology of
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prevention of neurologic disorders
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