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Diagnosis of Cerebral Amyloid Angiopathy G. , Stroke 28:1418-1422997., Greenberg,S.M.&Vonsattel,J-P, 1997 See this aricle in Pubmed Article Abstract The presence of vascular amyloid was a sensitive marker for CAA-related hemorrhage,occurring in all 28 specimens from brains with hemorrhage. Conversely,the appearance of fibrinoid necrosis in amyloid-laden vessels was relatively specific for CAA-related hemorrhage.This finding occurred in 13 of the 28 specimens(46%)from brains with hemorrhage but in none of 27 sections from brains with mild CAA and in only 4 of 42 specimens with moderate to severe CAA without hemorrhage.These data help to define criteria for the diagnosis of CAA-related hemorrhage from surgical specimens.

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