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Characterizing the Target of Acute Stroke Therapy
Stroke 28:866-872, Fisher,M., 1997
See this aricle in Pubmed

Article Abstract
Pathological identification of irreversibility(infarction)appears to lag behind the actual development of this condition,and reversible injury after focal ischemia should be differentiated from infarction.Imaging and biochemical markers apparently can provide clues for distinguishing potentially salvageable from irreversibly injured ischemic tissue in experimental and clinical stroke.Recent positron emission tomography and MRI studies suggest that these clinically available imaging technologies will be useful for determining the presence of ischemic penumbra in individual stroke patients.The progression from potentially reversible to irreversible injury after focal brain ischemia has many potential mechanisms that may be synergistic and vary among individuals.Delineating and prioritizing these mechanisms provides the opportunity to develop multiple potential acute stroke therapies that ultimately will be used in combination,perhaps directed by imaging technology.
 
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CAT scan,emission,abnormal
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cerebrovascular accident
cerebrovascular accident,acute management of
cerebrovascular accident,pathophysiology
ischemic penumbra
MRI
MRI,abnormal
MRI,diffusion weighted
MRI,early changes in CVA
neuroprotective agents
treatment of neurologic disorder

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