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A total of 61 lesions were present in 23 patients;12 patients(52%)had multiple lesions.All lesions were isointense or hypointense on T1-weighted images,and 53%were isointense or hypointense on T2-weighted images.Twenty patients received intravenous contrast material,and 43(91%)of 47 lesions enhanced.The three patients who had nonenhancing lesions received steroids before the initial MR studies.Enhancement patterns differed between the immunocompetent and the immunocompromised hosts,with the latter group harboring a higher percentage of rim-enhancing lesions.Twenty-seven(44$)of the lesions were centered in a cerebral hemisphere and 14(23%)were centered in the central gray matter.There was a statistically significant correlation between a higher degree of necrosis histologically and hyperintensity on T2-weighted MR images.The degree of necrosis also showed a positive correlation with rim enhancement.Primary CNS lymphoma has a variable MR appearance that correlates with the severity of intratumoral necrosis.These imaging characteristics,as well as lesion location,mean lesion size,and proclivity to harbor necrosis,are altered in the immunocompromised host. |
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acquired immunodeficiency syndrome
brainstem,neoplasms of
cerebellum,neoplasms of
gadolinium
lymphoma
lymphoma involving CNS
lymphoma,primary of CNS
MRI
MRI,abnormal
MRI,contrast enhanced
MRI,ring sign
neoplasm,posterior fossa
neoplasm,primary of CNS
neuropathology
review article
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