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Managing the Late Complications of Parkinson's Disease
Neurol 49:549-557, Waters,C.H., 1997
See this aricle in Pubmed

Article Abstract
Most patients with Parkinson's disease(PD)receiving chronic levodopa therapy eventually manifest one or more motor response complications, including"wearing-off"phenomena and"on-off"phenomena.Additionally,as the disease progresses,motor,neurologic,and neuropsychiatric complications increase and may include freezing spells,falls,dementia,depression,and psychosis.The management of patients with advanced PD presents a special clinical challenge because patients may experience an enhanced sensitivity to small changes in plasma levodopa levels and because they may suffer adverse reactions to antiparkinsonian drugs.Management of advanced PD is directed toward decreasing the dose of the offending drug while raising the dose of an alternative drug,with the goal of maintaining symptom control.In this article,the spectrum of late complications experienced by patients with advanced PD and their management are discussed.
 
Related Tags
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adverse drug reaction
clozapine
hallucination
L-dopa
L-dopa,drug interactions with and side effects of
movement disorder,drug induced
ondansetron
Parkinson disease
Parkinson disease,complications,late
Parkinson disease,treatment of
psychosis
psychotic behavior
sleep pathology and physiology
treatment of neurologic disorder

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