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Anticedents of Cerebral Palsy in a Multicenter Trial of Indomethacin for Intraventricular Hemorrhage
Arch Pediatr Adolesc Med 151:580-585, Allan,W.C.,et al, 1997
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Article Abstract
Cerebral palsy was found in 36(9.5%)of 381 infants at 36 months corrected age(range,33-39 months corrected age).Univariate analysis identified chorioammionitis,treatment with surfactant,bronchopulmonary dysplasia,and abnormal cranial US findings as antecedents of CP.Periventricular leukomalacia and ventriculomegaly were associated with highest detection rates for CP(37%and 30%respectively)with acceptable false-positive rates. Multivariate analysis identified bronchopulmonary dysplasia and an abnormal cranial US scan showing grade 3 to 4 intraventricular hemorrhage, periventricular leukomalacia or ventriculomegaly as independent predictors of CP.Odds ratios for the detection of CP using cranial US findings tabulated by hospital day were in the range of 7 to 26 beginning on day 2. The results suggest that cranial US findings are useful predictors of CP during a patient's stay in the hospital.
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cerebral palsy
cerebral palsy,risk factors
fetus
hydrocephalus
low birth weight
periventricular leukomalacia
premature infant
risk factors
ultrasonography
ultrasonography,head
ultrasonography,head,fetus-neonate
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