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For each 0.03 mm increase per year in carotid arterial intima-media thickness,the relative risk for nonfatal myocardial infarction or coronary death was 2.2(95%CI,1.4 to 3.6)and the relative risk for any coronary event was 3.1(CI,2.1 to 4.5)(P<0.001).Absolute intima-media thickness was also related to risk for clinical coronary events)P<0.02).Absolute thickness and progression in thickness predicted risk for coronary artery events beyond that predicted by coronary arterial measures of atherosclerosis and lipid measurements(P<0.001).Noninvasive B-mode ultrasonographic measurement of progression of intima-media thickness in the distal common carotid artery is a useful surrogate point for clinical coronary events. |
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