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Stroke is an important complication of sickle cell disease.Stroke prediction is clinically important because it offers the possibility of primary prevention.In 1992,transcranial Doppler(TCD)evidence of elevated intracranial internal carotid or middle cerebral artery velocity was demonstrated to be associated strongly with an increased risk of ischemic stroke.This study extends the original study and includes 125 more children,longer followup,and intracranial hemorrhage in the stroke-risk model.Elevated time averaged mean maximum blood flow velocity,especially when velocity is 200 cm/second or greater by TCD,was associated strongly with stroke risk.The cases not predicted by TCD point to the need for more information on the optimal timing of TCD surveillance for stroke risk. |
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carotid artery disease,noninvasive evaluation of
carotid artery stenosis
carotid artery stenosis,intracranial
cerebrovascular accident,infancy and childhood
cerebrovascular accident,prevention of
cerebrovascular disease,risk factors in
children
doppler
doppler,transcranial
risk factors
sickle cell disease
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