|
|
|
|
Total SPECT scanning time was 20 to 25 minutes.At 24 hours,reperfusion was greater in rtPA patients compared with the placebo group(SGS score,7+/-9 versus 29+/-17;p=.05),with relative improvement in the region-of-interest scores of 87+/-16%after rtPA compared with 28+/-30%with placebo(P=.01).A substantial perfusion defect exists in stroke patients with larger hemispheric infarcts who meet NINDS criteria for rtPA therapy,and rtPA is better able than placebo to rectify this defect.SPECT is feasible for clinical trials and should be evaluated as a substituted end point in stroke therapeutic trials. |
|