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No pretreatment information significantly affected patients'response to t- PA.The power of the model to detect a treatment interaction was greater than 90%,and therefore the probability of a type II error is very low. Apart from t-PA therapy,outcome was related to age by deficit severity interaction,diabetes,age by blood pressure interaction,and early CT findings.These variables and interactions altered long-term patient outcome irrespective of t-PA treatment but did not after the likelihood of responding favorably to t-PA therapy.Patients should be selected for t-PA thrombolysis according to the guidelines published in the report of the NINDS t-PA Stroke Trial.Further subselection of patients,such as by age or stroke severity,is not supported by our post hoc analysis. |
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