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Asympt Spinal Cord Lesions in Clin Isolated Optic Nerve, Brain Stem, & Spinal Cord Synd Suggest of Demyel JNNP 64:353-357, O'Riordan,J.J.,et al, 1998 See this aricle in Pubmed Article Abstract Thirty three patients,mean age 31(16-46)were recruited.There were 14 men and 19 women.Brain MRI was abnormal in 22(67%);no patient was seen with abnormalities on only one or other sequence.Six patients(18%)displayed one or more gadolinium enhancing lesions on brain MRI.In the spinal cord,nine (27%)patients displayed one or more clinically silent lesions on FSE.Two patients showed one and two gadolinium enhancing lesions in the spinal cord respectively.This high incidence of spinal cord lesions emphasizes that asymptomatic demyelinating lesions may also involve clinically eloquent pathways.Follow up studies are required to determine their prognostic importance.

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