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From 536 patients with the CREST syndrome(calcinosis,Raynaud's phenomenon, esophageal dysmotility,sclerodactyly,and telangiectasis),seven were identified as having peripheral neuropathy not attributable to another cause.Peripheral neuropathy developed 0 to 25 years after their first symptoms of scleroderma.Based on these clinical and pathologic findings,we conclude that in the CREST syndrome multiple mononeuropathy,although occurring infrequently,occurs more frequently than by chance and necrotizing vasculitis is the cause of this multiple mononeuropathy. |
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