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We report on 2 patients who presented stiffness and spasms similar to those of stiff-man syndrome(SMS)that were limited to one leg for up to 11 years.Patients had serum glutamic acid decarboxylase(GAD)autoantibodies in high titer,clinical evidence of organ-specific autoimmunity,and electromyographic pattern of continuous motor unit activity with abnormally enhanced exteroceptive reflexes.The clinical and immunological profile suggests that this disorder may be a focal form of SMS. |
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