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Diagnosis of Cytomegalovirus Encephalitis in Pts with AIDS by Cytomegalovirus Genomes in Cells of Cerebrospinal Fluid
Neurol 50:693-697, Wildemann,B.,et al, 1998
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Article Abstract
A nested polymerase chain reaction(PCR)assay was used to determine the levels of cytomegalovirus(CMV)genomes in cells of CSF from 19 patients with AIDS and 12 human immunodeficiency virus type I(HIV-1)seronegative individuals with various neurologic disorders.Quantitation of CMV genomes in CSF cells is indicative of latent or productive CMV infection and is a reliable means for diagnosis of CMVE in patients with AIDS.Detection of a cutoff value of cellular CMV genomes by means of nonquantitative PCR may identify patients at risk for CMV infection of the CNS.
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acquired immunodeficiency syndrome
cerebrospinal fluid
cerebrospinal fluid,abnormal
cytomegalovirus infection
encephalitis
encephalitis,viral
neurologic disease,diagnoses of
polymerase chain reaction
viral infection,CNS
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