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The headache response rates with zolmitriptan doses>/=2.5mg were 44 to 51% at 1 hour,65 to 67%at 2 hours,and 75 to 78%at 4 hours(all significantly superior to placebo).Also,zolmitriptan effectively relieved migraine- associated symptoms such as nausea,photophobia and phonophobia,and reduced activity impairment.Rates of headache recurrence,headache persistence,and use of escape medication were lower with zolmitriptan doses>/=2.5mg than with placebo.In patients with persistent or recurrent headache,a second zolmitriptan dose effectively treated both headache and nonheadache symptoms.Zolmitriptan was well tolerated,with a lower incidence of adverse events being reported with doses/=5mg. Zolmitriptan is a well tolerated and effective acute migraine therapy providing rapid relief of migraine headache within 1 hour.A clear dose- response relationship between efficacy and tolerability suggests that 2. 5mg is the optimal initial dose for the acute treatment of a migraine attack. |
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