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We report a 57-year-old man with progressive symmetric weakness and fasciculation affecting the legs.Electromyography revealed fibrillations and neurogenic motor unit potentials in the leg muscles.Biopsy of a motor branch of the obturator nerve revealed axonal degeneration,loss of myelinated nerve fibers,and amyloidosis with deposits of lambda light chains.At 6-month follow-up,the patient manifested sensory and autonomic symptoms,and lambda light chains were first detected in the serum.In this case,diagnosis of amyloidosis remained elusive until motor nerve biopsy. |
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