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When divided by his or her age,an individual striatal NAA loss and lactate increase were found to directly correlate with the subject's CAG repeat numbers,with correlation coefficients of 0.8 and 0.7,respectively.Similar correlations were noted between postmortem cell loss and have versus CAG repeat length.Together,these data provide further evidence for an interaction between neuronal activation and defect in energy metabolism in HD that may extend to presymptomatic subjects. |
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