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Randomized Trial Comparing Two Different High Doses of Methylprednisolone in MS, A Clinical and MRI Study Neurol 50:1833-1836, Oliveri,R.L.,et al, 1998 See this aricle in Pubmed Article Abstract Both treatment regimens improved clinical scores and reduced the number of MR enhancing lesions during the follow-up period.The higher doses of IVMP was significantly more effective than the lower dose in reducing the number of MRI contrast-enhanced lesions at 30 and 60 days,mainly by decreasing the rate of new lesion formation.The higher dosage of IVMP has a more powerful and prolonged action in maintaining blood-brain barrier integrity after a clinical relapse.

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