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Random, Placebo-Contr Study of Tolcapone in Pts with Fluctuating Parkinson Dis Trtd With Levodopa-Carbidopa
Arch Neurol 55:1089-1095, Adler,C.H.,et al, 1998
See this aricle in Pubmed
Article Abstract
Tolcapone was well tolerated and substantially increased on time and reduced off time in patients with fluctuating Parkinson disease. Additionally,levodopa requirements were significantly decreased.
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catechol-o-methyltransferase inhibitor
L-dopa
Parkinson disease
Parkinson disease,fluctuations in
Parkinson disease,on-off phenomena in
Parkinson disease,treatment of
sinemet
tolcapone
treatment of neurologic disorder
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