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The Value of Interphase Cytogenetics in Cytology for the Diagnosis of Leptomeningeal Metastases Neurol 51:906-908, Van Oostengrugge,R.J.,et al, 1998 See this aricle in Pubmed Article Abstract We studied the use of fluorescence in situ hybridization(FISH)in CSF to enhance the diagnostic yield for the detection of malignancy on the first lumbar puncture in patients clinically suspected of having leptomeningeal metastases(LMM).Although repeated lumbar punctures were still needed in some patients,the use of FISH did speed up the diagnosis in approximately one-third of the patients clinically suspected of having LMM with atypical cells at first cytology.This eliminates the need for repeated lumbar punctures in these patients and enables an earlier start of treatment

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,abnormal cerebrospinal fluid,biochemical markers of CNS tumors cerebrospinal fluid,cytology fluorescene in situ hybridization meningitis,carcinomatous meningitis,leukemic meningitis,lymphomatous neurologic disease,diagnoses of

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