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This article reviews diagnosis of cerebral amyloid angiopathy(CAA)during life and possible approaches to prevention.A clinical diagnosis of" probable CAA"can be made in patients aged 60 years or older with multiple hemorrhages confined to lobar brain regions and no other cause of hemorrhage.Gradient-echo MRI facilitates diagnosis by showing previous hemorrhages with high sensitivity.This technique can also mark the progression of CAA,as 50%of studied patients developed new petechial hemorrhages during 1.5 years of follow-up.The apolipoprotein E e2 and e4 alleles are associated with increased risk and earlier age of first hemorrhage,but are neither sensitive nor specific for CAA.The major remaining challenges are to develop new markers for the presence of CAA and treatment to block vascular amyloid deposition and vessel breakdown. |
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amyloid angiopathy,cerebral anticoagulant,complications of anticoagulant,contraindications anticoagulant,treatment apolipoprotein E atrial fibrillation cerebrovascular accident,prevention of intracerebral hemorrhage intracerebral hemorrhage,lobar intracerebral hemorrhage,multiple intracerebral hemorrhage,recurrent MRI MRI,abnormal MRI,gradient-echo MRI,serial neurologic disease,diagnoses of old age,neurology of prevention of neurologic disorders review article risk factors
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