Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Hereditary Cerebral Cavernous Angiomas:Clinical and Genetic Features in 57 French Families
Lancet 352:1892-1897, Labauge,P.,et al, 1998
See this aricle in Pubmed

Article Abstract
On MRI, 16 of 22 sporadic index patients had relatives with cavernous angiomas. 51 multiple-case families, including 100 patients with symptoms and 164 symptom-free individuals had MRI lesions. Most FCC patients had multiple lesions and there was a strong correlation between number of lesions and age (p<0.01). The sensitivity of gradient-echo sequences was higher than that of standard MRI for detection of small cavernous angiomas. Pattern of inheritance was autosomal dominant, with incomplete clinical penetrance. The occurrence of denovo mutations was strongly suggested in some families. Neuroimaging penetrance of FCC is much higher than clinical penetrance. 75% of sporadic cases with multiple lesions are in fact familial cases. The proportion of patients developing clinical symptoms is higher in hereditary form in the sporadic from of the disorder.
 
Related Tags
(click to filter results - removes previous filter)

cavernous hemangioma
familial
genetic neurologic disorders
malformation,vascular
malformation,vascular,cerebral
malformation,vascular,familial
MRI
MRI,abnormal
MRI,gradient-echo
review article

Click Here to return To Results