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Spatz-Lindenberg Disease,A Rare Cause of Vascular Dementia Stroke 30:687-689, Larner,A.J.,et al, 1999 See this aricle in Pubmed Article Abstract A 58-year-old woman presented with dementia and pyramidal signs. Neuroimaging showed multiple areas of white matter change. Brain biopsy showed intimal thickening of the walls of leptomeningeal and intraparenchymal arteries, almost to complete occlusion, with an intact internal elastic lamina and media and without inflammation or infiltraiton. The cortex showed only moderate gliosis. Spatz-Lindenberg disease should be considered in the differential diagnosis of vascular dementia. Additional studies of its pathogenesis are required to determine appropriate treatment.

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