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Surgical Treatment and Risk of Sporadic Creutzfeldt-Jakob Disease:A Case-Control Study
Lancet 353:693-697, Collins,S.,et al, 1999
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Article Abstract
Surgical procedures were significantly associated with the development of sporadic CJD. This risk progressively increased with the number of surgical treatments to a maximum for three procedures. There was also a significant association between risk of CJD and residence or employment on a farm (p<0.001) or market garden (p=0.002) for longer than 10 years. We found no significant risk associated with a history of blood transfusion, organ transplantation, major dental work, or occupation. Our findings accord with the hypothesis that a range of surgical treatments may serve as unrecognised contamination events and account for a proportion of cases of sporadic CJD. Possible biases in different methods and times for the acquisition of data on cases and controls suggest our findings need to be replicated in independent studies with community controls.
 
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epidemiology of neurology
farmer
iatrogenic neurologic disorders
Jakob-Creutzfeldt disease
Jakob-Creutzfeldt disease,medical precaution with
neurologic complications of,surgery
occupational neurologic disorders
risk factors
spongy degeneration of brain

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