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Use of the Polymerase Chain Reaction in the Diagnosis of Herpes Simplex Encephalitis:A Decision Analysis Model
Am J Med 105:287-295, Tebas,P.,et al, 1998
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Article Abstract
Using these input values, the decision model predicted better outcomes with empiric therapy. However, low rates of inappropriate discontinuation of empiric therapy in patients with herpes simplex encephalitis or improved diagnosis and outcome resulting from a negative PCR assay result in patients without herpes simplex encephalitis led to better outcomes with the PCR-based approach. The PCR-based approach was associated with 9.2 fewer doses of acyclovir per patient. Based on the decision model using conservative assumptions, a PCR-based approach can yield better outcomes and reduced acyclovir use compared with empiric therapy.
 
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acyclovir
cerebrospinal fluid
cerebrospinal fluid,abnormal
encephalitis,diagnosis of
herpes simplex encephalitis
herpes simplex encephalitis,diagnosis of
neurologic disease,diagnoses of
polymerase chain reaction

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