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The authors report two patients with testicular cancer who exhibited supranuclear gaze disorders as a manifestation of a paraneoplastic brainstem encephalomyelitis. In the first patient, neuro- ophthalmic dysfunction was accompanied by a prominent limbic encephalitis whereas in the second patient, an unusual, mixed pendular and jerk nystagmus was manifested. Neuroimaging revealed an enhancing hypohtalamic mass in the first patient and was negative in the second. Blood from both patients contained an antibody previously reported in a patients with limbic encephalitis and testicular cancer. |
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carcinoma of testis down-beat nystagmus down-beat nystagmus,primary position of gaze encephalitis,brainstem gaze palsy,supranuclear gaze palsy,vertical hypothalamus hypothalamus,damage to limbic encephalitis MRI MRI,abnormal neuroophthalmology nystagmus nystagmus,pendular oculogyric crisis remote effect of cancer on the nervous system
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