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High-Altitude Cerebral Edema Evaluated with Magnetic Resonance Imaging JAMA 280:1920-1925, Hackett,P.H.,et al, 1998 See this aricle in Pubmed Article Abstract We conclude that HACE is characterized on MRI by reversible white matter edema with a predilection for the splenium of the corpus callosum. This finding provides a clinical imaging correlate useful for diagnosis. It also suggests that the predominant mechanism is vasogenic (movement of fluid and protein out of the vascular compartment) and thus, that the blood-brain barrier may be important in HACE.

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