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Amitriptyline (AT) is a standard therapy for postherpetic neuralgia (PHN). Our hypothesis was that nortriptyline (NT), a noradrenergic metabolite of AT may be more effective. We concluded that this study provides a scientific basis for an analgesic action of NT in PHN because pain relief occurred without an antidepressant effect and that although there were fewer side effects with NT, AT and NT appear to have a similar analgesic action for most individuals. |
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