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Epileptology of the First-Seizure Presentation:A Clinical,Electroencephalographic,and Magnetic Resonance Imaging Study of 300 Consecutive Patients
Lancet 352:1007-1011,1003, King,M.A.,et al, 1998
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Article Abstract
A generalized or partial epilepsy syndrome was clinically diagnosed in 141 (47%) patients. Subsequent analysis showed that only three of these clinical diagnoses were incorrect. Addition of the EEG data enabled us to diagnose an epilepsy syndrome in 232 (77%) patients. EEG within 24 hours was more useful in diagnosis of epileptiform abnormalities than later EEG (51 vs 34%). Neuroimaging showed 38 epileptogenic lesions including 17 tumors. There were no lesions in patients for whom generalized epilepsy was confirmed by EEG. Our final diagnoses were : generalized epilepsy (23% of our patients),; partial epilepsy (58%) and unclassified (19%). An epilepsy syndrome can be diagnosed in most first-seizure patients. Ideally, an EEG should be obtained within the first 24 hours of the seizures followed by a sleep-deprived EEG if necessary. MRI aids diagnosis and should be done for all patients except for those with idiopathic generalized epilepsies and for children with benign rolandic epilepsy.
 
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