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Treating Repetitive Seizures with a Rectal Diazepam Formulation,A Randomized Study Neurol 51:1274-1282, Cereghino,J.J.,et al, 1998 See this aricle in Pubmed Article Abstract To evaluate the effectiveness and safety of a single-dose treatment for acute repetitive seizure (ARS) episodes (e.g., clusters) administered in a nonmedical setting by caregivers. Administration of a single rectal dose of Diastat was significantly more effective than placebo in reducing the number of seizures following an episode of ARS. Caregivers could administer treatment safely and effectively in a nonmedical setting.

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