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Acute and Reversible Parkinsonism Due to Organophosphate Pesticide Intoxication, Five Cases Neurol 52:1467-1471, Bhatt,M.H.,et al, 1999 See this aricle in Pubmed Article Abstract All patients developed parkinsonism that resembled PD clinically except for poor response to levodopa. Three genetically related patients were exposed to pesticides in a common environment before onset of parkinsonism; other family members remained unaffected. Other secondary causes of parkinsonism were excluded. Four patients recovered completely without treatment, and one patient was lost to follow-up. One patient experienced repeated episodes of parkinsonism with inadvertent reexposur e to a pesticide-contaminated environment. The clinical course of these five patients suggests their syndrome represents a heretofore undescribed toxic effect of OP pesticides. Our observations strengthen epidemiologic studies implicating OP pesticides in the etiology of PD. A genetic susceptibility to OP pesticide-induced parkinsonism may account for three family members developing this syndrome.

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(click to filter results - removes previous filter) insecticides neurotoxin Parkinson disease,acute onset Parkinsonism syndrome poison,neurologic problems with poison,organophosphate toxins,nervous system

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