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Topiramate Placebo-Controlled Dose-Ranging Trial in Refractory partial Epilepsy Using 200-, 400-, and 600-mg Daily Dosages Neurol 46:1684-1690, Faught,E.,et al, 1996 See this aricle in Pubmed Article Abstract The minimal effective dose of topiramate in this study population was approximately 200 mg/day. Mild or moderate CNS symptoms were the primary treatment-emergent adverse events, but treatment-limiting adverse events occurred in only 9% of pa tients given topiramate compared with 7% given placebo. Results of this initial well-controlled study in patients indicate that topiramate is a very promising new AED.

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(click to filter results - removes previous filter) seizure seizure,focal seizure,intractable seizure,intractable,treatment of seizure,psychomotor-temporal lobe seizure,treatment of topiramate treatment of neurologic disorder

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