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Topiramate in Clinical Practice:First Year's Postlicensing Experience in a Specialist Epilepsy Clinic JNNP 66:759-763, Kellett,M.W.,et al, 1999 See this aricle in Pubmed Article Abstract Adverse events (CNS related) were the most common reason for stopping topiramate. Eight patients with partial and one patient with juvenile myoclonic epilepsy became seizure free. There is a significant (20-25%) chance of being intolerant t o topiramate at relatively low doses. Substituting topiramate for another antiepileptic drug may reduce the chances of drug withdrawal. If topiramate is tolerated there is a good chance of worthwhile improvement in seizure control. These data, although not derived from randomised controlled trials, represent pragmatic use of novel antiepileptic drugs in "real life" and may be helpful to non-specialists when prescribing topiramate.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants,cognitive function with anticonvulsants,effectiveness anticonvulsants,untoward effects of cognition juvenile myoclonus epilepsy seizure seizure,focal seizure,paradoxical seizure,treatment of topiramate treatment of neurologic disorder

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