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Eleven randomized, placebo-controlled trials contributed a total of 5228 patient randomized to aspirin only and 4401 patients randomized to placebo only. The slope of the dose-response curve was virtually flat across a wide range of aspir in doses from 50 to 1400mg/d (P = .49 for test of slope not = to 0). Summarizing across studies, aspirin decreases the risk of stroke by about 15% (risk ratio, 0.85; 95% confidence interval, 0.77-0.94). Aspirin reduces the risk of stroke by approximatel y 15%, and this effect is uniform across aspirin doses from 50 to 1500mg/d. The lowest effective aspirin dose has not yet been identified, but it could be lower than 50 mg/d. |
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