Click Here to return To Results

 

High Incidence of Secondary Brain Tumours after Radiotherapy and Antimetabolites Lancet 354:34-39, Relling,M.V.,et al, 1999 See this aricle in Pubmed Article Abstract The 8-year cumulative incidence of brain tumour among children with defective versus wild-type thiopurine methyltransferase phenotype was 42.9% (SE 20.6) versus 8.3% (4.7; p=0.0077). This protocol differed from previous protocols, in that more intensive systemic antimetabolite therapy was given before and during radiotherapy. These data support the elimination of prophylactic radiotherapy for acute lymphoblastic leukaemia except in patients at high risk of central-nervous-system relapse. Underlying genetic characteristics and treatment variables may be associated with an increased risk of radiation-associated brain tumors.

Related Tags

(click to filter results - removes previous filter) astrocytoma chemotherapy,CNS treatment and complications with children glioblastoma multiforme(astrocytoma Gr.III) glioma iatrogenic neurologic disorders leukemia leukemia,prophylactic treatment of CNS neoplasm,primary of CNS radiation therapy,CNS treatment and complications with treatment of neurologic disorder

Click Here to return To Results