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Rapid-Onset Dystonia-Parkinsonism:Linkage to Chromosome 19q13 Ann Neurol 46:176-182, Kramer,P.L.,et al, 1999 See this aricle in Pubmed Article Abstract Rapid onset dystonia-parkinsonism (RPD) is an autosomal dominant movement disorder characterized by sudden onset of persistent dystonia and parkinsonism, generally during adolescence or early adulthood. The flanking markers D19S587 and D19 S900 define a candidate region of approximately 8 cM. Although RDP itself is a rare condition, it is important because it has clinical and biochemical similarities to both Parkinson's disease and dystonia. Identification of the genetic defect in RDP hol ds promise for understanding the underlying disease processes of both of these more common diseases.

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(click to filter results - removes previous filter) chromosome 19 dystonia familial genetic neurologic disorders Parkinson disease,dystonia with Parkinson disease,L-dopa nonresponsive Parkinson disease,rapid onset Parkinsonism syndrome

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