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Interferon-B-1a in Relapsing-Remitting Multiple Sclerosis:Effect on Hypointense Lesion Volume on T1 Weighted Images JNNP 67:579-584, Gasperini,C.,et al, 1999 See this aricle in Pubmed Article Abstract There was a significant increase in the mean hyperintense lesion volume during the pretreatment phase (6 months) and a slight decrease during the treatment period (12 months), whereas the hypointense lesion volume increased significantly be fore treatment and remained substantially stable during treatment. There was a significant correlation between changes in hypointense and hyperintense lesion volume during the observation period, but not during treatment. The monthly mean volume of Gado linium-DTPA enhancing lesions was significantly higher during the pretreatment than the treatment period, and the enhancing lesion volume correlated with changes of hyperintense and hypointense lesion volumes only during the observation period. These dat a suggest that interferon-beta-1a has a stabilising effect on T1 weighted hypointense lesion volume.

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(click to filter results - removes previous filter) interferon interferon beta 1-a MRI MRI,abnormal MRI,black holes on MRI,hypointense signal foci on MRI,serial multiple sclerosis multiple sclerosis,treatment of treatment of neurologic disorder

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