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This pilot study demonstrates combined IV/IA treatment is feasible and provides better recanalization, although it was not associated with improved clinical outcomes. The presence of thrombus on initial arteriography was directly related to the baseline NIHSSS. This approach is technically feasible. The numbers of symptomatic ICH were similar between the 2 groups, which suggests that this approach may be safe. Further study is needed to determine the safety and effectiveness of this ne w method of treatment. Such studies should address not only efficacy and safety but also the cost-benefit ratio and quality of life, given the major investment in time, personnel, and equipment required by combined IV and IA techniques. |
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cerebrovascular accident,acute management of
cerebrovascular accident,thrombolytic agents in treatment
cost effectiveness
fibrinolytic agents
fibrinolytic agents,intra-arterial local infusion
recanalization,arterial
tissue plasminogen activator,intravenous
treatment of neurologic disorder
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